| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY26107.1 | EKY26443.1 | HMPREF0216_02146 | HMPREF0216_01939 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | 0.695 |
| EKY26107.1 | EKY27654.1 | HMPREF0216_02146 | HMPREF0216_01297 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | Ribose-5-phosphate isomerase B; KEGG: cbe:Cbei_0407 2.2e-60 RpiB/LacA/LacB family sugar-phosphate isomerase K01808; Psort location: Cytoplasmic, score: 7.50. | 0.567 |
| EKY26107.1 | EKY28426.1 | HMPREF0216_02146 | HMPREF0216_00777 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | Class II glutamine amidotransferase. | 0.764 |
| EKY26107.1 | fhs | HMPREF0216_02146 | HMPREF0216_02543 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.822 |
| EKY26107.1 | folD | HMPREF0216_02146 | HMPREF0216_01602 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.887 |
| EKY26107.1 | glyA | HMPREF0216_02146 | HMPREF0216_02267 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
| EKY26107.1 | purH | HMPREF0216_02146 | HMPREF0216_02023 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | KEGG: cpe:CPE0686 5.5e-215 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.699 |
| EKY26107.1 | purN | HMPREF0216_02146 | HMPREF0216_02024 | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.693 |
| EKY26247.1 | EKY26443.1 | HMPREF0216_02029 | HMPREF0216_01939 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | 0.709 |
| EKY26247.1 | EKY28426.1 | HMPREF0216_02029 | HMPREF0216_00777 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Class II glutamine amidotransferase. | 0.908 |
| EKY26247.1 | fhs | HMPREF0216_02029 | HMPREF0216_02543 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.954 |
| EKY26247.1 | folD | HMPREF0216_02029 | HMPREF0216_01602 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.887 |
| EKY26247.1 | glyA | HMPREF0216_02029 | HMPREF0216_02267 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
| EKY26247.1 | purH | HMPREF0216_02029 | HMPREF0216_02023 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | KEGG: cpe:CPE0686 5.5e-215 purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50. | 0.999 |
| EKY26247.1 | purN | HMPREF0216_02029 | HMPREF0216_02024 | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| EKY26443.1 | EKY26107.1 | HMPREF0216_01939 | HMPREF0216_02146 | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbb:CLD_2935 5.6e-103 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 7.50. | 0.695 |
| EKY26443.1 | EKY26247.1 | HMPREF0216_01939 | HMPREF0216_02029 | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbt:CLH_1037 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.709 |
| EKY26443.1 | EKY27654.1 | HMPREF0216_01939 | HMPREF0216_01297 | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | Ribose-5-phosphate isomerase B; KEGG: cbe:Cbei_0407 2.2e-60 RpiB/LacA/LacB family sugar-phosphate isomerase K01808; Psort location: Cytoplasmic, score: 7.50. | 0.679 |
| EKY26443.1 | EKY28426.1 | HMPREF0216_01939 | HMPREF0216_00777 | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | Class II glutamine amidotransferase. | 0.941 |
| EKY26443.1 | fhs | HMPREF0216_01939 | HMPREF0216_02543 | KEGG: cbt:CLH_0670 9.2e-261 NADH oxidase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbe:Cbei_0101 2.5e-251 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. | 0.700 |