STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (651 aa)    
Predicted Functional Partners:
EKY27305.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.998
EKY23874.1
MutS domain V protein; KEGG: bal:BACI_c37190 1.2e-114 mutS; DNA mismatch repair protein K03555; Psort location: Cytoplasmic, score: 7.50.
 
 0.998
EKY23873.1
KEGG: btk:BT9727_3510 3.8e-81 mutS; DNA mismatch repair protein MutS K03555; Psort location: Cytoplasmic, score: 7.50.
 
 0.995
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 0.990
EKY28915.1
MutS domain V protein; KEGG: edi:EDI_294890 1.8e-18 DNA mismatch repair protein MSH2; Psort location: Cytoplasmic, score: 7.50.
 
 0.987
EKY22287.1
MutS domain V protein; KEGG: btk:BT9727_3510 2.3e-15 mutS; DNA mismatch repair protein MutS K03555; Psort location: CytoplasmicMembrane, score: 10.00.
 
 0.981
miaA
tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
  
 0.873
EKY22199.1
KEGG: cpe:CPE0343 1.2e-217 recQ; ATP-dependent DNA helicase RecQ; K03654 ATP-dependent DNA helicase RecQ; Psort location: Cytoplasmic, score: 9.89.
  
 0.853
EKY28185.1
ATP-dependent DNA helicase RecQ.
  
 0.826
hfq
RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
     
 0.780
Your Current Organism:
Clostridium celatum
NCBI taxonomy Id: 545697
Other names: C. celatum DSM 1785, Clostridium celatum DSM 1785
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.