| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY23233.1 | EKY23235.1 | HMPREF0216_03018 | HMPREF0216_03020 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | 0.821 |
| EKY23233.1 | EKY23236.1 | HMPREF0216_03018 | HMPREF0216_03021 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cpr:CPR_1421 1.6e-178 hemD; uroporphyrinogen-III methyltransferase/synthase K13542; Psort location: Cytoplasmic, score: 7.50. | 0.977 |
| EKY23233.1 | EKY23238.1 | HMPREF0216_03018 | HMPREF0216_03023 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: clj:CLJU_c31990 2.5e-36 sirC; precorrin-2 dehydrogenase; Psort location: Cytoplasmic, score: 7.50. | 0.930 |
| EKY23233.1 | EKY25834.1 | HMPREF0216_03018 | HMPREF0216_02320 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cpe:CPE1040 7.5e-108 threonine-phosphate decarboxylase K04720. | 0.745 |
| EKY23233.1 | cbiA | HMPREF0216_03018 | HMPREF0216_03179 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.847 |
| EKY23233.1 | cobD | HMPREF0216_03018 | HMPREF0216_02319 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.773 |
| EKY23233.1 | cobQ | HMPREF0216_03018 | HMPREF0216_02325 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.860 |
| EKY23233.1 | cobS | HMPREF0216_03018 | HMPREF0216_02316 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Cobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.779 |
| EKY23233.1 | hemC | HMPREF0216_03018 | HMPREF0216_03022 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.751 |
| EKY23233.1 | hemL | HMPREF0216_03018 | HMPREF0216_03019 | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: cpf:CPF_1685 2.1e-174 hemL; glutamate-1-semialdehyde aminotransferase K01845; Psort location: Cytoplasmic, score: 9.97. | 0.759 |
| EKY23235.1 | EKY23233.1 | HMPREF0216_03020 | HMPREF0216_03018 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | 0.821 |
| EKY23235.1 | EKY23236.1 | HMPREF0216_03020 | HMPREF0216_03021 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | KEGG: cpr:CPR_1421 1.6e-178 hemD; uroporphyrinogen-III methyltransferase/synthase K13542; Psort location: Cytoplasmic, score: 7.50. | 0.999 |
| EKY23235.1 | EKY23238.1 | HMPREF0216_03020 | HMPREF0216_03023 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | KEGG: clj:CLJU_c31990 2.5e-36 sirC; precorrin-2 dehydrogenase; Psort location: Cytoplasmic, score: 7.50. | 0.851 |
| EKY23235.1 | EKY25834.1 | HMPREF0216_03020 | HMPREF0216_02320 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | KEGG: cpe:CPE1040 7.5e-108 threonine-phosphate decarboxylase K04720. | 0.564 |
| EKY23235.1 | cbiA | HMPREF0216_03020 | HMPREF0216_03179 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.579 |
| EKY23235.1 | cobD | HMPREF0216_03020 | HMPREF0216_02319 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.473 |
| EKY23235.1 | cobQ | HMPREF0216_03020 | HMPREF0216_02325 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.506 |
| EKY23235.1 | hemC | HMPREF0216_03020 | HMPREF0216_03022 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| EKY23235.1 | hemL | HMPREF0216_03020 | HMPREF0216_03019 | Porphobilinogen synthase; KEGG: ctc:CTC00729 1.1e-124 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 7.50; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: cpf:CPF_1685 2.1e-174 hemL; glutamate-1-semialdehyde aminotransferase K01845; Psort location: Cytoplasmic, score: 9.97. | 0.997 |
| EKY23236.1 | EKY23233.1 | HMPREF0216_03021 | HMPREF0216_03018 | KEGG: cpr:CPR_1421 1.6e-178 hemD; uroporphyrinogen-III methyltransferase/synthase K13542; Psort location: Cytoplasmic, score: 7.50. | Cobalt chelatase; KEGG: cpr:CPR_1242 9.9e-35 anaerobic cobalt chelatase, CbiK; K02190 sirohydrochlorin cobaltochelatase; Psort location: Cytoplasmic, score: 7.50. | 0.977 |