| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKY22285.1 | EKY22286.1 | HMPREF0216_03329 | HMPREF0216_03330 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | Exonuclease; KEGG: bce:BC3538 3.5e-09 exonuclease; Psort location: Cytoplasmic, score: 7.50. | 0.764 |
| EKY22285.1 | EKY22381.1 | HMPREF0216_03329 | HMPREF0216_03269 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.596 |
| EKY22285.1 | EKY26097.1 | HMPREF0216_03329 | HMPREF0216_02136 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbk:CLL_A2867 7.1e-25 V-type sodium ATP synthase subunit G; K02121 V-type H+-transporting ATPase subunit E. | 0.618 |
| EKY22285.1 | EKY26110.1 | HMPREF0216_03329 | HMPREF0216_02149 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | 0.782 |
| EKY22285.1 | EKY28407.1 | HMPREF0216_03329 | HMPREF0216_00758 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | Putative glycine betaine/carnitine/choline transport system permease protein opuCD; KEGG: saa:SAUSA300_0707 6.8e-43 osmoprotectant ABC transporter, permease K05845:K05846; Psort location: CytoplasmicMembrane, score: 10.00. | 0.857 |
| EKY22285.1 | EKY28408.1 | HMPREF0216_03329 | HMPREF0216_00759 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | ABC transporter, substrate-binding protein, QAT family. | 0.857 |
| EKY22285.1 | EKY29379.1 | HMPREF0216_03329 | HMPREF0216_00240 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | DHHA2 domain protein; KEGG: cpr:CPR_2027 2.0e-217 putative manganese-dependent inorganic pyrophosphatase K01507; Psort location: Cytoplasmic, score: 9.97. | 0.840 |
| EKY22285.1 | addA | HMPREF0216_03329 | HMPREF0216_01081 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | ATP-dependent nuclease subunit A; ATP-dependent DNA helicase. | 0.581 |
| EKY22285.1 | guaA | HMPREF0216_03329 | HMPREF0216_03257 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.936 |
| EKY22285.1 | purA | HMPREF0216_03329 | HMPREF0216_00109 | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.633 |
| EKY22286.1 | EKY22285.1 | HMPREF0216_03330 | HMPREF0216_03329 | Exonuclease; KEGG: bce:BC3538 3.5e-09 exonuclease; Psort location: Cytoplasmic, score: 7.50. | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | 0.764 |
| EKY22381.1 | EKY22285.1 | HMPREF0216_03269 | HMPREF0216_03329 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | 0.596 |
| EKY22381.1 | EKY29379.1 | HMPREF0216_03269 | HMPREF0216_00240 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | DHHA2 domain protein; KEGG: cpr:CPR_2027 2.0e-217 putative manganese-dependent inorganic pyrophosphatase K01507; Psort location: Cytoplasmic, score: 9.97. | 0.604 |
| EKY22381.1 | guaA | HMPREF0216_03269 | HMPREF0216_03257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.931 |
| EKY22381.1 | purA | HMPREF0216_03269 | HMPREF0216_00109 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.887 |
| EKY26097.1 | EKY22285.1 | HMPREF0216_02136 | HMPREF0216_03329 | KEGG: cbk:CLL_A2867 7.1e-25 V-type sodium ATP synthase subunit G; K02121 V-type H+-transporting ATPase subunit E. | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | 0.618 |
| EKY26097.1 | EKY29379.1 | HMPREF0216_02136 | HMPREF0216_00240 | KEGG: cbk:CLL_A2867 7.1e-25 V-type sodium ATP synthase subunit G; K02121 V-type H+-transporting ATPase subunit E. | DHHA2 domain protein; KEGG: cpr:CPR_2027 2.0e-217 putative manganese-dependent inorganic pyrophosphatase K01507; Psort location: Cytoplasmic, score: 9.97. | 0.818 |
| EKY26110.1 | EKY22285.1 | HMPREF0216_02149 | HMPREF0216_03329 | KEGG: cbk:CLL_A2853 3.0e-271 5-methyltetrahydrofolate--homocysteine methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50. | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | 0.782 |
| EKY28407.1 | EKY22285.1 | HMPREF0216_00758 | HMPREF0216_03329 | Putative glycine betaine/carnitine/choline transport system permease protein opuCD; KEGG: saa:SAUSA300_0707 6.8e-43 osmoprotectant ABC transporter, permease K05845:K05846; Psort location: CytoplasmicMembrane, score: 10.00. | CBS domain protein; KEGG: phe:Phep_1434 1.7e-05 cysteine synthase; K01697 cystathionine beta-synthase; Psort location: Cytoplasmic, score: 7.50. | 0.857 |
| EKY28407.1 | EKY28408.1 | HMPREF0216_00758 | HMPREF0216_00759 | Putative glycine betaine/carnitine/choline transport system permease protein opuCD; KEGG: saa:SAUSA300_0707 6.8e-43 osmoprotectant ABC transporter, permease K05845:K05846; Psort location: CytoplasmicMembrane, score: 10.00. | ABC transporter, substrate-binding protein, QAT family. | 0.999 |