STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucAKEGG: nme:NMB0955 0. 2-oxoglutarate dehydrogenase, E1 component K00164; Psort location: Cytoplasmic, score: 9.26. (964 aa)    
Predicted Functional Partners:
sucB
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
lpdA-2
Dihydrolipoyl dehydrogenase; KEGG: nma:NMA1556 0. lpdA; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) K00382; Psort location: Cytoplasmic, score: 9.97.
 
 0.999
lpdA
Dihydrolipoyl dehydrogenase; KEGG: ngo:NGO0915 1.2e-247 dldH; dihydrolipoamide dehydrogenase K00382; Psort location: Cytoplasmic, score: 9.97.
 
 0.988
EFC89800.1
Dihydrolipoyl dehydrogenase; KEGG: nma:NMA1142 1.6e-245 lpdA2; putative dihydrolipoamide dehydrogenase K00382; Psort location: Cytoplasmic, score: 9.97.
  
 0.979
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.979
aceF
Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.953
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 
 0.932
sdhB
KEGG: ngo:NGO0920 1.0e-131 putative succinate dehydrogenase K00240; Psort location: Cytoplasmic, score: 8.96; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.929
sdhA
KEGG: nma:NMA1145 0. sdhA; succinate dehydrogenase flavoprotein subunit K00239; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.927
sdhC
KEGG: nme:NMB0948 4.7e-54 succinate dehydrogenase cytochrome b-556 subunit K00241; Psort location: CytoplasmicMembrane, score: 10.00.
 
  
 0.922
Your Current Organism:
Neisseria mucosa
NCBI taxonomy Id: 546266
Other names: N. mucosa ATCC 25996, Neisseria mucosa ATCC 25996, Neisseria mucosa str. ATCC 25996, Neisseria mucosa strain ATCC 25996
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.