STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (434 aa)    
Predicted Functional Partners:
purB
KEGG: nme:NMB0284 5.3e-229 adenylosuccinate lyase K01756; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.992
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.989
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.974
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: nma:NMA1182 9.1e-273 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.971
EFC88531.1
KEGG: ngo:NGO2035 1.1e-91 hypoxanthine-guanine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.935
pyrB
KEGG: nma:NMA0168 1.2e-149 pyrB; aspartate carbamoyltransferase catalytic chain K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.931
argG
KEGG: nma:NMA0303 2.5e-238 argG; argininosuccinate synthase K01940; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
   
 
 0.927
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.914
EFC87755.1
Aminotransferase, class I/II; KEGG: nma:NMA0719 6.7e-206 aspC; putative aspartate aminotransferase K00813; Psort location: Cytoplasmic, score: 9.26.
   
 0.913
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.910
Your Current Organism:
Neisseria mucosa
NCBI taxonomy Id: 546266
Other names: N. mucosa ATCC 25996, Neisseria mucosa ATCC 25996, Neisseria mucosa str. ATCC 25996, Neisseria mucosa strain ATCC 25996
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