STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB99879.1COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006099:IPR006159:IPR006158:IPR006098; KEGG: vpr:Vpar_1762 methylmalonyl-CoA mutase, large subunit; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; Cobalamin (vitamin B12)-binding; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-CoA mutase, large subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; Methylmalonyl-CoA mutase, C-terminal; IMG reference gene:2504586388; PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylma [...] (731 aa)    
Predicted Functional Partners:
AEB99476.1
LAO/AO transport system ATPase; COGs: COG1703 Putative periplasmic protein kinase ArgK and related GTPase of G3E family; InterPro IPR003593:IPR005129; KEGG: vpr:Vpar_1246 LAO/AO transport system ATPase; PFAM: ArgK protein; SMART: ATPase, AAA+ type, core; SPTR: LAO/AO transport system ATPase; TIGRFAM: ArgK protein; IMG reference gene:2504585963; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase.
  
 0.994
AEB99880.1
LAO/AO transport system ATPase; COGs: COG1703 Putative periplasmic protein kinase ArgK and related GTPase of G3E family; InterPro IPR005129; KEGG: vpr:Vpar_1761 LAO/AO transport system ATPase; PFAM: ArgK protein; SPTR: LAO/AO transport system ATPase; TIGRFAM: ArgK protein; IMG reference gene:2504586389; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase.
 
  
 0.992
mce
methylmalonyl-CoA epimerase; InterPro IPR004360:IPR017515; KEGG: vpr:Vpar_1245 methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Methylmalonyl-CoA epimerase; TIGRFAM: Methylmalonyl-CoA epimerase; IMG reference gene:2504585964; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: methylmalonyl-CoA epimerase.
 
  
 0.983
AEB99878.1
COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006099:IPR006098; KEGG: vpr:Vpar_1763 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-CoA mutase beta subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; IMG reference gene:2504586387; PFAM: Methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase, heterodimeric type, beta chain.
 
 
0.960
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.957
AEB99473.1
Succinate CoA transferase; COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR017821:IPR003702:IPR006472; KEGG: toc:Toce_1836 succinate CoA transferase; PFAM: Acetyl-CoA hydrolase/transferase; Citrate lyase, alpha subunit; PRIAM: Acetyl-CoA hydrolase; SPTR: Coenzyme A transferase PsecoA; TIGRFAM: Succinate CoA transferase; IMG reference gene:2504585960; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases.
  
 
 0.949
nifJ
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR019456:IPR011895:IPR002880:IPR011766:IPR 019752; KEGG: cbi:CLJ_B2987 pyruvate ferredoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate-flavodoxin oxidoreductase, EKR domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; PRIAM: Pyruvate dehydrogenase (NADP(+)); SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; SPTR: Pyruvate-flavodoxin oxidoreductase; [...]
    
 0.944
sucC
Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.935
AEC00612.1
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
    
 0.892
AEC01132.1
COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: csh:Closa_2133 citrate synthase; PFAM: Citrate synthase-like; SPTR: 2-methylcitrate synthase; IMG reference gene:2504587703; PFAM: Citrate synthase; Belongs to the citrate synthase family.
     
 0.886
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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