Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEC00861.1dCMP deaminase; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125; KEGG: fnu:FN1902 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase, zinc-binding; PRIAM: dCMP deaminase; SPTR: Putative deoxycytidylate deaminase; IMG reference gene:2504587402; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (163 aa)    
Predicted Functional Partners:
AEB99717.1
COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR004843; KEGG: afn:Acfer_0834 5'-nucleotidase domain protein; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase family protein; IMG reference gene:2504586215; PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family.
  
 
  0.931
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.919
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
  0.910
cmk
COGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR003136:IPR000623:IPR011994; KEGG: sth:STH1668 cytidylate kinase; PFAM: Cytidylate kinase domain; Shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase; IMG reference gene:2504586727; PFAM: Cytidylate kinase; Rad17 cell cycle checkpoint protein; TIGRFAM: cytidylate kinase.
    
  0.901
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
     
  0.900
AEC00862.1
COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR004089; KEGG: slp:Slip_1365 methyl-accepting chemotaxis sensory transducer; PFAM: Chemotaxis methyl-accepting receptor, signalling; SMART: Chemotaxis methyl-accepting receptor, signalling; SPTR: Putative methyl-accepting chemotaxis protein signaling domain protein; IMG reference gene:2504587403; PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain.
       0.773
AEC00863.1
COGs: COG0589 Universal stress protein UspA and related nucleotide-binding protein; InterPro IPR006016; KEGG: vpr:Vpar_0306 UspA domain protein; PFAM: UspA; SPTR: Universal stress protein; IMG reference gene:2504587404; PFAM: Universal stress protein family.
       0.773
AEC00023.1
Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000587:IPR000994; KEGG: tte:TTE1280 Xaa-Pro aminopeptidase; PFAM: Peptidase M24, structural domain; Creatinase; SPTR: Xaa-Pro dipeptidase; IMG reference gene:2504586543; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain; Belongs to the peptidase M24B family.
  
  
 0.680
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.667
Your Current Organism:
Selenomonas sputigena
NCBI taxonomy Id: 546271
Other names: S. sputigena ATCC 35185, Selenomonas sputigena ATCC 35185, Selenomonas sputigena DSM 20758, Selenomonas sputigena HMP_JCVI_SC0180, Selenomonas sputigena str. ATCC 35185, Selenomonas sputigena strain ATCC 35185
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