STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (205 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 0.999
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.998
pyrK
Oxidoreductase NAD-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
 
 0.986
pyrC
Amidohydrolase family protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.978
pyrB
KEGG: fnu:FN0419 7.9e-149 pyrB; aspartate carbamoyltransferase catalytic subunit K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.972
carB
KEGG: fnu:FN0422 0. carB; carbamoyl phosphate synthase large subunit K01955; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.957
carA
KEGG: fnu:FN0421 1.1e-188 carbamoyl phosphate synthase small subunit K01956; Psort location: Cytoplasmic, score: 8.96; Belongs to the CarA family.
  
  
 0.941
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.861
pyrR
Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
  
 0.817
EFE85647.1
Histidinol phosphate phosphatase HisJ family; KEGG: fnu:FN0428 3.2e-113 hypothetical protein K04486; Psort location: Cytoplasmic, score: 8.96; Belongs to the PHP hydrolase family. HisK subfamily.
       0.794
Your Current Organism:
Fusobacterium periodonticum
NCBI taxonomy Id: 546275
Other names: F. periodonticum ATCC 33693, Fusobacterium periodonticum ATCC 33693, Fusobacterium periodonticum str. ATCC 33693, Fusobacterium periodonticum strain ATCC 33693
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