STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.999
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 
 0.998
SFW90833.1
Lipoate-protein ligase A.
 
 
 0.983
SFW69668.1
Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family.
 
 0.974
SFW69644.1
Sarcosine oxidase subunit alpha; Belongs to the GcvT family.
 
 0.970
SFW90708.1
Dihydrolipoamide dehydrogenase.
 
  
 0.963
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.962
SFW71986.1
Dihydrolipoamide dehydrogenase.
 
  
 0.953
SFW66415.1
2-oxoglutarate decarboxylase.
  
 0.945
gcvH-2
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
  
 
0.924
Your Current Organism:
Amycolatopsis australiensis
NCBI taxonomy Id: 546364
Other names: A. australiensis, Amycolatopsis australiensis Tan et al. 2006, Amycolatopsis sp. GY048, Amycolatopsis sp. GY049, Amycolatopsis sp. GY056, Amycolatopsis sp. GY064, Amycolatopsis sp. GY269, Amycolatopsis sp. GY276, Amycolatopsis sp. GY286, DSM 44671, JCM 15587, NCIMB 14142, strain GY048
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