Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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clpBPutative Chaperone clpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (852 aa)    
Predicted Functional Partners:
dnaK
Putative Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.890
clpP
Putative Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.771
grpE
Putative Protein grpE, HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...]
  
 
 0.758
clpS
Putative ATP-dependent Clp protease adaptor protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
 
 0.684
ACO46033.1
Putative heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.679
ACO46796.1
Putative heat shock protein; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.679
dnaJ
Putative Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]
  
 
 0.615
ACO47230.1
Putative Chaperone DnaJ-like protein.
  
 
 0.596
ACO46179.1
Putative Branched-chain amino acid ABC transporter, permease component; Belongs to the binding-protein-dependent transport system permease family.
       0.530
ACO46180.1
Putative Branched-chain amino acid ABC transporter, permease component; Belongs to the binding-protein-dependent transport system permease family.
       0.530
Your Current Organism:
Deinococcus deserti
NCBI taxonomy Id: 546414
Other names: D. deserti VCD115, Deinococcus deserti VCD115, Deinococcus deserti str. VCD115, Deinococcus deserti strain VCD115
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