STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuAPutative 2-isopropylmalate synthase (Isopropylmalate synthase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.980
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.972
ilvD
Putative dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.971
ACO45797.1
Putative Branched-chain-amino-acid transaminase (Branched-chain amino acid aminotransferase); Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.960
ilvB
Putative acetolactate synthase, large subunit.
 
 
 0.943
ilvH
Putative Acetolactate synthase, small subunit.
 
 
 0.937
ACO46341.1
Putative Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.924
phbA
Putative Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
ACO45178.1
Putative Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.921
acsA
Putative acetate--CoA ligase (Acyl-activating enzyme, Acetyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.921
Your Current Organism:
Deinococcus deserti
NCBI taxonomy Id: 546414
Other names: D. deserti VCD115, Deinococcus deserti VCD115, Deinococcus deserti str. VCD115, Deinococcus deserti strain VCD115
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.