STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1614 aa)    
Predicted Functional Partners:
WRN
Werner syndrome ATP-dependent helicase.
   
 0.995
mcl1
Minichromosome loss protein 1.
   
 
 0.984
ssb1
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.983
dnr-8
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.977
exo1
Exodeoxyribonuclease 1.
   
 0.973
FEN1A
Flap endonuclease 1-A.
   
 0.960
elg1
Telomere length regulation protein elg1.
   
 0.937
pif1-0
ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
  
 
 
 0.927
ssb2
Replication factor A protein 2.
   
 0.920
recQ
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
   
 0.917
Your Current Organism:
Colletotrichum trifolii
NCBI taxonomy Id: 5466
Other names: BBA 70709, BPI 399624, C. trifolii, CBS 158.83
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