SDR78687.1 protein (Friedmanniella luteola) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SDR78687.1

Predicted peroxiredoxin. (123 aa)

Predicted Functional Partners:

SDS03853.1

0.838

SDR78633.1

0.516

SDR78662.1

0.516

SDT20516.1

0.447

Your Current Organism:

Friedmanniella luteola

NCBI taxonomy Id: 546871
Other names: DSM 21741, F. luteola, Friedmanniella luteola Iwai et al. 2010, Friedmanniella sp. FA1, NBRC 104963, strain FA1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDR78633.1	SDR78662.1	SAMN04488543_0463	SAMN04488543_0464	Hypothetical protein.	Ribosomal protection tetracycline resistance protein.	0.773
SDR78633.1	SDR78687.1	SAMN04488543_0463	SAMN04488543_0465	Hypothetical protein.	Predicted peroxiredoxin.	0.516
SDR78662.1	SDR78633.1	SAMN04488543_0464	SAMN04488543_0463	Ribosomal protection tetracycline resistance protein.	Hypothetical protein.	0.773
SDR78662.1	SDR78687.1	SAMN04488543_0464	SAMN04488543_0465	Ribosomal protection tetracycline resistance protein.	Predicted peroxiredoxin.	0.516
SDR78687.1	SDR78633.1	SAMN04488543_0465	SAMN04488543_0463	Predicted peroxiredoxin.	Hypothetical protein.	0.516
SDR78687.1	SDR78662.1	SAMN04488543_0465	SAMN04488543_0464	Predicted peroxiredoxin.	Ribosomal protection tetracycline resistance protein.	0.516
SDR78687.1	SDS03853.1	SAMN04488543_0465	SAMN04488543_0957	Predicted peroxiredoxin.	tRNA 2-thiouridine synthesizing protein A; Belongs to the sulfur carrier protein TusA family.	0.838
SDR78687.1	SDT20516.1	SAMN04488543_0465	SAMN04488543_3299	Predicted peroxiredoxin.	Protein of unknown function.	0.447
SDS03853.1	SDR78687.1	SAMN04488543_0957	SAMN04488543_0465	tRNA 2-thiouridine synthesizing protein A; Belongs to the sulfur carrier protein TusA family.	Predicted peroxiredoxin.	0.838
SDT20516.1	SDR78687.1	SAMN04488543_3299	SAMN04488543_0465	Protein of unknown function.	Predicted peroxiredoxin.	0.447

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.854

expected number of edges:

12

PPI enrichment p-value:

2.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006526

Arginine biosynthetic process

9 of 12

2.34

7.22

9.47e-17

GO:0009084

Glutamine family amino acid biosynthetic process

10 of 19

2.19

7.0

7.99e-18

GO:1901605

Alpha-amino acid metabolic process

11 of 129

1.4

2.67

1.68e-13

GO:0006591

Ornithine metabolic process

3 of 3

2.47

2.35

3.89e-05

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.47

1.35

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008777

Acetylornithine deacetylase activity

2 of 2

2.47

0.74

0.0457

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1199

0.39

0.27

0.0492

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:17425781

(2007) A novel bifunctional N-acetylglutamate synthase-kinase from Xanthomonas campestris that is closely related to mammalian N-acetylglutamate synthase.

7 of 8

2.41

5.81

9.70e-13

PMID:16409639

(2006) Bioinformatic analysis of an unusual gene-enzyme relationship in the arginine biosynthetic pathway among marine gamma proteobacteria: implications concerning the formation of N-acetylated intermediates in prokaryotes.

3 of 3

2.47

2.14

9.92e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1776

Lysine biosynthetic process, and Arginine biosynthetic process

9 of 18

2.17

6.29

8.92e-16

CL:1774

Glutamine family amino acid biosynthetic process, and Lysine biosynthesis

10 of 26

2.05

6.16

6.00e-17

CL:1798

Arginine biosynthetic process

5 of 5

2.47

4.24

4.90e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00220

Arginine biosynthesis

7 of 20

2.01

4.36

4.03e-11

map01230

Biosynthesis of amino acids

10 of 139

1.33

2.22

4.03e-11

map01210

2-Oxocarboxylic acid metabolism

4 of 33

1.55

0.00018

map00250

Alanine, aspartate and glutamate metabolism

3 of 23

1.58

1.27

0.0015

map01110

Biosynthesis of secondary metabolites

8 of 420

0.75

0.64

0.00030

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

8 of 10

2.37

6.65

5.14e-15

KW-0170

Cobalt

2 of 8

1.87

0.83

0.0251

KW-0963

Cytoplasm

7 of 247

0.92

0.82

0.00030

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