node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDU85806.1 | SDU89445.1 | SAMN04488544_1057 | SAMN04488544_1577 | Cystathionine gamma-synthase. | Hypothetical protein. | 0.699 |
SDU85806.1 | SDU91219.1 | SAMN04488544_1057 | SAMN04488544_1858 | Cystathionine gamma-synthase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.979 |
SDU85806.1 | SDU95287.1 | SAMN04488544_1057 | SAMN04488544_2494 | Cystathionine gamma-synthase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.770 |
SDU85806.1 | SDU96883.1 | SAMN04488544_1057 | SAMN04488544_2745 | Cystathionine gamma-synthase. | Cystathionine gamma-lyase. | 0.888 |
SDU85806.1 | SDU96993.1 | SAMN04488544_1057 | SAMN04488544_2762 | Cystathionine gamma-synthase. | Cystathionine beta-synthase. | 0.996 |
SDU85806.1 | metK | SAMN04488544_1057 | SAMN04488544_1475 | Cystathionine gamma-synthase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.834 |
SDU89445.1 | SDU85806.1 | SAMN04488544_1577 | SAMN04488544_1057 | Hypothetical protein. | Cystathionine gamma-synthase. | 0.699 |
SDU89445.1 | SDU91219.1 | SAMN04488544_1577 | SAMN04488544_1858 | Hypothetical protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.972 |
SDU89445.1 | SDU95287.1 | SAMN04488544_1577 | SAMN04488544_2494 | Hypothetical protein. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.882 |
SDU89445.1 | SDU96883.1 | SAMN04488544_1577 | SAMN04488544_2745 | Hypothetical protein. | Cystathionine gamma-lyase. | 0.699 |
SDU89445.1 | SDU96993.1 | SAMN04488544_1577 | SAMN04488544_2762 | Hypothetical protein. | Cystathionine beta-synthase. | 0.834 |
SDU89445.1 | glyA | SAMN04488544_1577 | SAMN04488544_0043 | Hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.502 |
SDU89445.1 | metK | SAMN04488544_1577 | SAMN04488544_1475 | Hypothetical protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.903 |
SDU91219.1 | SDU85806.1 | SAMN04488544_1858 | SAMN04488544_1057 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-synthase. | 0.979 |
SDU91219.1 | SDU89445.1 | SAMN04488544_1858 | SAMN04488544_1577 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein. | 0.972 |
SDU91219.1 | SDU95287.1 | SAMN04488544_1858 | SAMN04488544_2494 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
SDU91219.1 | SDU96883.1 | SAMN04488544_1858 | SAMN04488544_2745 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-lyase. | 0.979 |
SDU91219.1 | SDU96993.1 | SAMN04488544_1858 | SAMN04488544_2762 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-synthase. | 0.943 |
SDU91219.1 | folD | SAMN04488544_1858 | SAMN04488544_0227 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.854 |
SDU91219.1 | gcvT | SAMN04488544_1858 | SAMN04488544_2607 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |