STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AGG14383.1Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; IMG reference gene:2506376923; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; KEGG: hth:HTH_1097 2-oxoglutarate:ferredoxin oxidoreductase gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoredu [...] (226 aa)    
Predicted Functional Partners:
AGG14384.1
Thiamine pyrophosphate TPP-binding domain-containing protein; IMG reference gene:2506376924; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding; KEGG: hth:HTH_1096 2-oxoglutarate:ferredoxin oxidoreductase beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766.
 
 0.998
AGG14385.1
IMG reference gene:2506376925; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: hth:HTH_1095 2-oxoglutarate:ferredoxin oxidoreductase alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880.
 
 0.995
AGG15915.1
Thiamine pyrophosphate TPP-binding domain-containing protein; IMG reference gene:2506378545; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tal:Thal_0792 thiamine pyrophosphate protein domain protein TPP-binding protein; InterPro IPR011766.
 
 0.992
AGG15914.1
IMG reference gene:2506378544; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Transketolase, C-terminal domain; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain-containing protein; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: hth:HTH_1553 pyruvate:ferredoxin oxidoreductase alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880:IPR005476:IPR000209.
 
 0.985
AGG14382.1
2-oxoglutarate:ferredoxin oxidoreductase epsilon subunit, ferredoxin-like protein; IMG reference gene:2506376922; SPTR: Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit-like protein; KEGG: hth:HTH_1098 2-oxoglutarate:ferredoxin oxidoreductase epsilon subunit, ferredoxin-like protein; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR017896.
  
 
 0.983
AGG14950.1
Oxaloacetate decarboxylase alpha subunit; IMG reference gene:2506377518; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit; TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; SPTR: Oxaloacetate decarboxylase alpha subunit; KEGG: aae:aq_1614 pyruvate carboxylase subunit B; COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterProIPR005776:IPR001882:IPR000891:IPR003379:IPR 000089.
   
 
 0.915
AGG14898.1
Pyruvate kinase; IMG reference gene:2506377463; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; TIGRFAM: pyruvate kinase; PRIAM: Pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; SPTR: Pyruvate kinase; KEGG: sul:SYO3AOP1_0383 pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015794; Belongs to the pyruvate kinase family.
    
 0.914
AGG15369.1
IMG reference gene:2506377968; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; SPTR: Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit-like protein; KEGG: tal:Thal_0795 pyruvate:ferredoxin oxidoreductase; InterPro IPR017896.
  
 
 0.912
AGG14429.1
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.907
AGG15868.1
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
    
 0.907
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
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