STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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trpEAnthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (496 aa)    
Predicted Functional Partners:
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.999
AGG15511.1
IMG reference gene:2506378113; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; SPTR: Indole-3-glycerol-phosphate synthase; KEGG: tal:Thal_1059 indole-3-glycerol-phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798; Belongs to the TrpC family.
 
 0.999
AGG15756.1
Glutamine amidotransferase of anthranilate synthase; IMG reference gene:2506378376; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; KEGG: aae:aq_549 anthranilate synthase component II; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926:IPR006220:IPR011702:IPR001317:IPR 000991:IPR006221.
 0.999
AGG14464.1
Prephenate dehydratase; IMG reference gene:2506377012; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Prephenate dehydratase; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 002701:IPR008242.
 
 
 0.963
trpF
Phosphoribosylanthranilate isomerase; IMG reference gene:2506378165; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; PRIAM: Phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; KEGG: aae:aq_2076 phosphoribosyl anthranilate isomerase; COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; Belongs to the TrpF family.
 
  
 0.949
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.930
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.924
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.884
AGG15634.1
Chorismate binding protein; IMG reference gene:2506378240; PFAM: chorismate binding enzyme; PFAM: Chorismate binding-like; SPTR: Chorismate binding-like protein; KEGG: aae:aq_1144 p-aminobenzoate synthetase; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR015890.
  
  
 
0.851
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
    
 0.832
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
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