STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AGG15133.1IMG reference gene:2506377718; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain of tRNA; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase valyl/leucyl anticodon-binding; SPTR: tRNA synthetase valyl/leucyl anticodon-binding; KEGG: aae:aq_1770 leucyl-tRNA synthetase beta subunit; COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR002300:IPR013155. (275 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthetase beta subunit; IMG reference gene:2506377779; PFAM: tRNA synthetase B5 domain; Ferredoxin-fold anticodon binding domain; B3/4 domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase, beta subunit; KEGG: aae:aq_1730 phenylalanyl-tRNA synthetase subunit beta; COGs: COG0072 Phenylalanyl-tRNA sy [...]
  
  
 0.984
AGG15366.1
leucyl-tRNA synthetase; IMG reference gene:2506377965; PFAM: Leucyl-tRNA synthetase, Domain 2; tRNA synthetases class I (I, L, M and V); TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); SPTR: Leucyl-tRNA synthetase; KEGG: aae:aq_351 leucyl-tRNA synthetase alpha subunit; COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR001412:IPR002302:IPR015413; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
     0.976
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
 
 0.958
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
0.944
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
  
 0.939
argS
arginyl-tRNA synthetase; IMG reference gene:2506377288; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; PRIAM: Arginine--tRNA ligase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; SPTR: Arginyl-tRNA synthetase; KEGG: aae:aq_923 arginyl-tRNA synthetase; COGs: COG0018 Arginyl-tRNA synthetase; InterProIPR001278:IPR015945:IPR001412:IPR005148:IPR 008909.
  
 0.905
AGG14545.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); IMG reference gene:2506377097; PFAM: EAL domain; GGDEF domain; GAF domain; PAS domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; TIGRFAM: diguanylate cyclase; PAS sensor protein; KEGG: sul:SYO3AOP1_0011 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); C [...]
   
   0.884
AGG15481.1
Diguanylate cyclase with PAS/PAC sensor; IMG reference gene:2506378082; PFAM: CBS domain; GGDEF domain; PAS domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; CBS domain containing protein; PAS fold domain protein; SMART: GGDEF domain containing protein; CBS domain containing protein; PAS domain containing protein; SPTR: Diguanylate cyclase with PAS/PAC sensor; KEGG: saf:SULAZ_1315 GGDEF domain protein; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000014:IPR000160:IPR000644:IPR013767.
   
   0.879
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
 
 0.850
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
 
0.837
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
Server load: low (18%) [HD]
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