STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGG15512.1Carboxymethylenebutenolidase; IMG reference gene:2506378114; PFAM: Dienelactone hydrolase family; PRIAM: Carboxymethylenebutenolidase; SPTR: Carboxymethylenebutenolidase; KEGG: hth:HTH_1817 carboxymethylenebutenolidase; COGs: COG0412 Dienelactone hydrolase. (214 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
    0.775
AGG15510.1
Signal peptide protein peptidase SppA, 36K type; IMG reference gene:2506378112; PFAM: Peptidase family S49; TIGRFAM: signal peptide peptidase SppA, 36K type; TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; SPTR: Signal peptide peptidase SppA, 36K type; KEGG: hth:HTH_0236 signal peptide peptidase; COGs: COG0616 Periplasmic serine protease (ClpP class); InterPro IPR002142:IPR004635.
       0.773
AGG15511.1
IMG reference gene:2506378113; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; SPTR: Indole-3-glycerol-phosphate synthase; KEGG: tal:Thal_1059 indole-3-glycerol-phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798; Belongs to the TrpC family.
       0.773
AGG15514.1
Putative signal transduction protein; IMG reference gene:2506378116; PFAM: HDOD domain; PFAM: Metal-dependent hydrolase HDOD; SPTR: Putative signal transduction protein; KEGG: pmx:PERMA_0610 EAL domain protein; COGs: COG3434 signal transduction protein containing EAL and modified HD-GYP domains; InterPro IPR013976.
       0.773
AGG15515.1
IMG reference gene:2506378117; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; KEGG: hth:HTH_0638 acetolactate synthase small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789.
       0.737
AGG15516.1
Acetolactate synthase, large subunit; IMG reference gene:2506378118; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; SPTR: Acetolactate synthase; KEGG: hth:HTH_0637 acetolactate synthase large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamin [...]
       0.731
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
    0.671
AGG15506.1
Type IV pilus assembly PilZ; IMG reference gene:2506378108; PFAM: PilZ domain; PFAM: type IV pilus assembly PilZ; SPTR: Type IV pilus assembly PilZ; KEGG: pmx:PERMA_1005 type IV pilus assembly protein PilZ; InterPro IPR009875.
       0.664
uvrA
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
       0.664
AGG15508.1
Hypothetical protein; IMG reference gene:2506378110; PFAM: NYN domain; TIGRFAM: TIGR00288 family protein; SPTR: Putative uncharacterized protein; KEGG: aae:aq_430 hypothetical protein; COGs: COG1432 conserved hypothetical protein.
       0.664
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
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