node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGG15530.1 | AGG15535.1 | HydHO_1216 | HydHO_1221 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | 0.768 |
AGG15530.1 | AGG15536.1 | HydHO_1216 | HydHO_1222 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | 0.722 |
AGG15530.1 | hflX | HydHO_1216 | HydHO_1220 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.768 |
AGG15530.1 | hfq | HydHO_1216 | HydHO_1219 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.768 |
AGG15530.1 | ispG | HydHO_1216 | HydHO_1218 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.777 |
AGG15535.1 | AGG15530.1 | HydHO_1221 | HydHO_1216 | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.768 |
AGG15535.1 | AGG15536.1 | HydHO_1221 | HydHO_1222 | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | 0.763 |
AGG15535.1 | hflX | HydHO_1221 | HydHO_1220 | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.786 |
AGG15535.1 | hfq | HydHO_1221 | HydHO_1219 | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.779 |
AGG15535.1 | ispG | HydHO_1221 | HydHO_1218 | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.779 |
AGG15536.1 | AGG15530.1 | HydHO_1222 | HydHO_1216 | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.722 |
AGG15536.1 | AGG15535.1 | HydHO_1222 | HydHO_1221 | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | Hypothetical protein; IMG reference gene:2506378137; SPTR: Putative uncharacterized protein; KEGG: hth:HTH_0782 hypothetical protein. | 0.763 |
AGG15536.1 | hflX | HydHO_1222 | HydHO_1220 | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.738 |
AGG15536.1 | hfq | HydHO_1222 | HydHO_1219 | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.730 |
AGG15536.1 | ispG | HydHO_1222 | HydHO_1218 | Aldo/keto reductase; IMG reference gene:2506378138; PFAM: Aldo/keto reductase family; PFAM: aldo/keto reductase; SPTR: Aldo/keto reductase; KEGG: aae:aq_323 hypothetical protein; COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR001395. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.781 |
dxr | ispD | HydHO_0096 | HydHO_1276 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.988 |
dxr | ispE | HydHO_0096 | HydHO_1395 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.817 |
dxr | ispF | HydHO_0096 | HydHO_1156 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.859 |
dxr | ispG | HydHO_0096 | HydHO_1218 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.886 |
dxr | ispH | HydHO_0096 | HydHO_1043 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.840 |