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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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AGG15551.1Integral membrane sensor signal transduction histidine kinase; IMG reference gene:2506378153; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Integral membrane sensor signal transduction histidine kinase; KEGG: saf:SULAZ_1134 putative two-component sensor histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR005467:IPR003594. (357 aa)    
Predicted Functional Partners:
kdpE
Two component transcriptional regulator, winged helix family, KdpE; IMG reference gene:2506378154; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; KEGG: saf:SULAZ_1135 transcriptional activator protein IrlR; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867.
 
 
 0.963
cheY
Two component transcriptional regulator, winged helix family, CheY KdpE; IMG reference gene:2506377257; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; KEGG: saf:SULAZ_1135 transcriptional activator protein IrlR; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867.
 
 
 0.837
cheY-2
Two component transcriptional regulator, winged helix family, CheY; IMG reference gene:2506378062; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; KEGG: tal:Thal_0320 two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR00 [...]
 
 
 0.830
cheY-3
Two component transcriptional regulator, winged helix family, CheY; IMG reference gene:2506378175; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; KEGG: aae:aq_319 transcriptional regulator (PhoB-like); COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867.
 
 
 0.819
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.778
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
       0.775
AGG14551.1
Diguanylate cyclase; IMG reference gene:2506377103; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein; SPTR: Diguanylate cyclase; KEGG: tal:Thal_0682 diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160.
  
 
 0.737
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
     
 0.696
AGG15481.1
Diguanylate cyclase with PAS/PAC sensor; IMG reference gene:2506378082; PFAM: CBS domain; GGDEF domain; PAS domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; CBS domain containing protein; PAS fold domain protein; SMART: GGDEF domain containing protein; CBS domain containing protein; PAS domain containing protein; SPTR: Diguanylate cyclase with PAS/PAC sensor; KEGG: saf:SULAZ_1315 GGDEF domain protein; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000014:IPR000160:IPR000644:IPR013767.
 
 
 0.679
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.677
Your Current Organism:
Hydrogenobaculum sp. HO
NCBI taxonomy Id: 547144
Other names: H. sp. HO
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