node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFC05430.1 | SFD34776.1 | SAMN05216284_102348 | SAMN05216284_115108 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Mg/Co/Ni transporter MgtE (contains CBS domain). | 0.439 |
SFC05430.1 | SFD75940.1 | SAMN05216284_102348 | SAMN05216284_12424 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase. | 0.862 |
SFC05430.1 | guaA | SAMN05216284_102348 | SAMN05216284_10928 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.963 |
SFC05430.1 | guaB | SAMN05216284_102348 | SAMN05216284_10922 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.911 |
SFC05430.1 | purN | SAMN05216284_102348 | SAMN05216284_10956 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.604 |
SFD34730.1 | SFD34753.1 | SAMN05216284_115106 | SAMN05216284_115107 | Hypothetical protein. | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | 0.734 |
SFD34730.1 | SFD34776.1 | SAMN05216284_115106 | SAMN05216284_115108 | Hypothetical protein. | Mg/Co/Ni transporter MgtE (contains CBS domain). | 0.599 |
SFD34730.1 | SFD34792.1 | SAMN05216284_115106 | SAMN05216284_115109 | Hypothetical protein. | Uncharacterized membrane protein. | 0.599 |
SFD34730.1 | SFD34818.1 | SAMN05216284_115106 | SAMN05216284_115110 | Hypothetical protein. | ATP-binding protein involved in chromosome partitioning; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | 0.467 |
SFD34753.1 | SFD34730.1 | SAMN05216284_115107 | SAMN05216284_115106 | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | Hypothetical protein. | 0.734 |
SFD34753.1 | SFD34776.1 | SAMN05216284_115107 | SAMN05216284_115108 | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | Mg/Co/Ni transporter MgtE (contains CBS domain). | 0.606 |
SFD34753.1 | SFD34792.1 | SAMN05216284_115107 | SAMN05216284_115109 | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | Uncharacterized membrane protein. | 0.607 |
SFD34753.1 | SFD34818.1 | SAMN05216284_115107 | SAMN05216284_115110 | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | ATP-binding protein involved in chromosome partitioning; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | 0.455 |
SFD34776.1 | SFC05430.1 | SAMN05216284_115108 | SAMN05216284_102348 | Mg/Co/Ni transporter MgtE (contains CBS domain). | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.439 |
SFD34776.1 | SFD34730.1 | SAMN05216284_115108 | SAMN05216284_115106 | Mg/Co/Ni transporter MgtE (contains CBS domain). | Hypothetical protein. | 0.599 |
SFD34776.1 | SFD34753.1 | SAMN05216284_115108 | SAMN05216284_115107 | Mg/Co/Ni transporter MgtE (contains CBS domain). | Trans-2,3-dihydro-3-hydroxyanthranilate isomerase. | 0.606 |
SFD34776.1 | SFD34792.1 | SAMN05216284_115108 | SAMN05216284_115109 | Mg/Co/Ni transporter MgtE (contains CBS domain). | Uncharacterized membrane protein. | 0.959 |
SFD34776.1 | SFD34818.1 | SAMN05216284_115108 | SAMN05216284_115110 | Mg/Co/Ni transporter MgtE (contains CBS domain). | ATP-binding protein involved in chromosome partitioning; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | 0.662 |
SFD34776.1 | SFD75940.1 | SAMN05216284_115108 | SAMN05216284_12424 | Mg/Co/Ni transporter MgtE (contains CBS domain). | 5'-nucleotidase. | 0.665 |
SFD34776.1 | corA | SAMN05216284_115108 | SAMN05216284_12256 | Mg/Co/Ni transporter MgtE (contains CBS domain). | Magnesium transporter; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | 0.463 |