STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Mmah_0129COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804:IPR019818:IPR011828; KEGG: LYS12; homo- isocitrate dehydrogenase; K05824 homoisocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: Q46FW0 3-isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. (331 aa)    
Predicted Functional Partners:
hacB
3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...]
 
 0.998
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.996
Mmah_1162
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR002034; KEGG: gem:GM21_2146 homocitrate synthase; PFAM: pyruvate carboxyltransferase; SPTR: Q12XM1 2-isopropylmalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.965
Mmah_1938
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR002034; KEGG: gme:Gmet_1265 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; SPTR: Q12V56 2-isopropylmalate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like.
 
 
 0.927
leuC-2
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.891
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 0.876
cofC
Phospholactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
      
 0.839
cofH
FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
     
 0.834
cofH-2
FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
     
 0.834
Mmah_1754
Sulfopyruvate decarboxylase subunit alpha; COGs: COG4032 thiamine-pyrophosphate-binding protein; KEGG: scl:sce7306 hypothetical protein; SPTR: A5UJA7 Sulfopyruvate decarboxylase, comD; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain.
      
 0.820
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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