STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mmah_0651Hypothetical protein; SPTR: Q8PW30 Putative uncharacterized protein; PFAM: Gar1/Naf1 RNA binding region. (86 aa)    
Predicted Functional Partners:
truB
tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
   
 0.999
nop10
RNA-binding protein Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
   
 0.999
rpl7ae
LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
  
 0.985
Mmah_0136
Pre-mRNA processing ribonucleoprotein, binding domain protein; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687; KEGG: Hypothetical protein CBG14983; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; SPTR: Q12VQ9 rRNA biogenesis protein Nop56/Nop58; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
  
 
 0.915
tfb
Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
  
  
 0.779
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 
 0.674
Mmah_1100
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterProIPR001650:IPR011545:IPR014001:IPR014021:IPR 000629:IPR014014; KEGG: dvm:DvMF_2125 DEAD/DEAH box helicase domain protein; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: B8GGY3 DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
  
 
 0.672
guaAB
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.648
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 
 0.623
Mmah_0654
COGs: COG2520 methyltransferase; InterPro IPR013216:IPR003402; KEGG: TRM5; tRNA-(N1G37) methyltransferase; K07055; PFAM: protein of unknown function Met10; Methyltransferase type 11; SPTR: Q46CP0 Methyltransferase; PFAM: Met-10+ like-protein; TIGRFAM: methyltransferase, FkbM family.
  
  
 0.620
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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