STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argHCOGs: COG0165 Argininosuccinate lyase; InterPro IPR000362:IPR009049; KEGG: gur:Gura_0231 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Q8TR65 Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (492 aa)    
Predicted Functional Partners:
argG
COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518:IPR018223; KEGG: hypothetical protein; K01940 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Q12XK3 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 
 0.999
argB
N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.999
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.999
argD
COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814:IPR004636; KEGG: gsu:GSU0151 acetylornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: Q12U07 Acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.983
argJ
Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.973
Mmah_0591
COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR020557:IPR004769; KEGG: nam:NAMH_1763 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: Q8TJ18 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
  
0.933
Mmah_1232
COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: ppd:Ppro_2646 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Q8PY29 Amino-acid acetyltransferase; PFAM: Acetyltransferase (GNAT) family.
 
      0.897
Mmah_0390
NUDIX hydrolase; COGs: COG1051 ADP-ribose pyrophosphatase; InterPro IPR020476:IPR000086:IPR020084; KEGG: sfu:Sfum_1206 NUDIX hydrolase; PFAM: NUDIX hydrolase; SPTR: Q12U16 NUDIX hydrolase; PFAM: NUDIX domain.
    
 0.883
Mmah_0582
COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804; KEGG: ilo:IL0861 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: Q12X23 Isocitrate dehydrogenase (NADP); PFAM: Isocitrate/isopropylmalate dehydrogenase.
  
 
 0.859
Mmah_1107
COGs: COG0039 Malate/lactate dehydrogenase; InterPro IPR001557:IPR001236:IPR011275; KEGG: dol:Dole_2374 malate dehydrogenase, NAD-dependent; PFAM: Lactate/malate dehydrogenase; PRIAM: Malate dehydrogenase; SPTR: Q8PVJ7 Malate dehydrogenase; TIGRFAM: malate dehydrogenase, NAD-dependent; PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; TIGRFAM: malate dehydrogenase, NAD-dependent; Belongs to the LDH/MDH superfamily.
  
 0.857
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.