STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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Mmah_20233,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (242 aa)    
Predicted Functional Partners:
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.999
Mmah_1489
2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR002734:IPR011549:IPR006401; KEGG: pca:Pcar_1445 riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; PRIAM: 5-amino-6-(5-phosphoribosylamino)uracil reductase; SPTR: Q12TM0 2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; TIGRFAM:2,5-diamino-6-hydroxy-4-(5-phosphoribosylam ino)pyrimidine1-reductase; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; 2,5 [...]
 
 
 0.939
ribK
CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
       0.804
Mmah_1124
COGs: COG1731 riboflavin synthase; InterPro IPR002180:IPR006399; KEGG: bgl:bglu_1g07930 6,7-dimethyl-8-ribityllumazine synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase; PRIAM: Riboflavin synthase; SPTR: Q12YH9 Riboflavin synthase alpha chain; TIGRFAM: riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: riboflavin synthase.
 
   
 0.683
Mmah_0833
COGs: COG0550 Topoisomerase IA; InterProIPR000380:IPR013497:IPR006171:IPR013498:IPR 003601:IPR006154:IPR003602:IPR000572:IPR000209; KEGG: TOP3B; topoisomerase (DNA) III beta (EC:5.99.1.2); K03165 DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; DNA topoisomerase type IA zn finger domain protein; PRIAM: DNA topoisomerase; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein; SPTR: Q8TPW5 DNA topoisomerase; PFAM: Toprim domain; Topoisomerase DNA binding C4 zinc finger; DNA topoisomerase; TI [...]
     
 0.602
rps2
COGs: COG0052 Ribosomal protein S2; InterPro IPR001865:IPR018130:IPR005707; KEGG: 40S ribosomal protein S0; K02998 small subunit ribosomal protein SAe; PFAM: ribosomal protein S2; SPTR: Q12TI2 30S ribosomal protein S2P; TIGRFAM: ribosomal protein S2; PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein Sa(cytosolic)/S2(archaeal); Belongs to the universal ribosomal protein uS2 family.
 
  
 0.602
Mmah_1674
Sodium/proton antiporter, CPA1 family (TC 2.A.36); COGs: COG0025 NhaP-type Na+/H+ and K+/H+ antiporter; InterPro IPR006036:IPR006037:IPR003148:IPR006153; KEGG: dol:Dole_2292 sodium/hydrogen exchanger; PFAM: sodium/hydrogen exchanger; TrkA-N domain protein; TrkA-C domain protein; SPTR: Q12W95 Sodium/hydrogen exchanger; PFAM: TrkA-N domain; Sodium/hydrogen exchanger family; TrkA-C domain.
     
 0.589
Mmah_0515
COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085:IPR003382:IPR005252; KEGG: gbm:Gbem_1667 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: Q466Q5 Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopan [...]
 
   
 0.576
Mmah_2025
Ion transport protein; InterPro IPR003091:IPR013099:IPR005821; KEGG: dde:Dde_3005 potassium channel protein; PFAM: Ion transport protein; Ion transport 2 domain protein; SPTR: Q12VA9 Ion transport protein; PFAM: Ion transport protein.
   
   0.573
Mmah_2026
Copper-translocating P-type ATPase; COGs: COG2217 Cation transport ATPase; InterProIPR001757:IPR001756:IPR008250:IPR005834:IPR 018303:IPR006416:IPR006403; KEGG: bba:Bd2297 heavy-metal transporting CPx-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; SPTR: O30085 Probable copper-exporting P-type ATPase B; TIGRFAM: copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; haloacid dehalogenase-like hydrolase; TIGRFAM: copper-(or si [...]
     
 0.564
Your Current Organism:
Methanohalophilus mahii
NCBI taxonomy Id: 547558
Other names: M. mahii DSM 5219, Methanohalophilus mahii DSM 5219, Methanohalophilus mahii str. DSM 5219, Methanohalophilus mahii strain DSM 5219
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