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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflA_1Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)    
Predicted Functional Partners:
pflB_4
Formate acetyltransferase 1.
  
 0.965
tdcE_1
PFL-like enzyme TdcE.
  
 0.928
csdB
Putative formate acetyltransferase 3.
  
 0.864
AML37227.1
Formate acetyltransferase 2.
  
 0.808
focA
Putative formate transporter 1.
   
 0.804
grcA
Autonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins.
 
   
 0.788
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
      
 0.716
adhE_5
Aldehyde-alcohol dehydrogenase.
 
  
 0.648
rubB
Nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.647
porA
Putative pyruvate-flavodoxin oxidoreductase.
     
 0.517
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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