STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macA_1Macrolide export protein MacA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)    
Predicted Functional Partners:
macB
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 0.997
tolC_2
Outer membrane protein TolC.
  
 
 0.895
acrB_2
Putative aminoglycoside efflux pump.
 
 0.687
mexB_1
Multidrug efflux pump subunit AcrB.
 
 0.662
acrB_1
Multidrug export protein AcrF.
 
 0.642
acrB_3
Multidrug efflux pump subunit AcrB.
 
 0.640
bepE_1
Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.564
porA
Putative pyruvate-flavodoxin oxidoreductase.
   
   0.553
AML36229.1
Hypothetical protein.
       0.519
cusA
Cation efflux system protein CusA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
 
 0.471
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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