| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioA_2 | bioB | EAG7_02604 | EAG7_02603 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.998 |
| bioA_2 | bioC | EAG7_02604 | EAG7_02601 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | Malonyl-[acyl-carrier protein] O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.877 |
| bioA_2 | bioD1_1 | EAG7_02604 | EAG7_01742 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | ATP-dependent dethiobiotin synthetase BioD 2; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.992 |
| bioA_2 | bioD1_2 | EAG7_02604 | EAG7_02600 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | ATP-dependent dethiobiotin synthetase BioD 1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.999 |
| bioA_2 | bioF | EAG7_02604 | EAG7_02602 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.997 |
| bioA_2 | bioH_1 | EAG7_02604 | EAG7_04440 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | Pimelyl-[acyl-carrier protein] methyl ester esterase; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.598 |
| bioA_2 | birA_2 | EAG7_02604 | EAG7_03886 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | Bifunctional protein BirA. | 0.662 |
| bioA_2 | kbl | EAG7_02604 | EAG7_04246 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.790 |
| bioA_2 | panB_3 | EAG7_02604 | EAG7_03193 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase. | 0.755 |
| bioA_2 | yohJ | EAG7_02604 | EAG7_00472 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | UPF0299 membrane protein. | 0.622 |
| bioB | bioA_2 | EAG7_02603 | EAG7_02604 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | 0.998 |
| bioB | bioC | EAG7_02603 | EAG7_02601 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Malonyl-[acyl-carrier protein] O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.999 |
| bioB | bioD1_1 | EAG7_02603 | EAG7_01742 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | ATP-dependent dethiobiotin synthetase BioD 2; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.997 |
| bioB | bioD1_2 | EAG7_02603 | EAG7_02600 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | ATP-dependent dethiobiotin synthetase BioD 1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.999 |
| bioB | bioF | EAG7_02603 | EAG7_02602 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.997 |
| bioB | bioH_1 | EAG7_02603 | EAG7_04440 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Pimelyl-[acyl-carrier protein] methyl ester esterase; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.836 |
| bioB | birA_2 | EAG7_02603 | EAG7_03886 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional protein BirA. | 0.972 |
| bioB | kbl | EAG7_02603 | EAG7_04246 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.778 |
| bioB | panB_3 | EAG7_02603 | EAG7_03193 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase. | 0.437 |
| bioC | bioA_2 | EAG7_02601 | EAG7_02604 | Malonyl-[acyl-carrier protein] O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase. | 0.877 |
