Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lhgOL-2-hydroxyglutarate oxidase LhgO; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa)    
Predicted Functional Partners:
csiD
Protein CsiD; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
  
 
 0.997
AML35744.1
Hypothetical protein.
 
  
 0.937
gabD_2
Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; Belongs to the aldehyde dehydrogenase family.
  
  
 0.820
gabT
4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.809
csiR
HTH-type transcriptional repressor CsiR.
 
  
 0.755
gabP
GABA permease.
  
  
 0.548
porA
Putative pyruvate-flavodoxin oxidoreductase.
     
 0.470
dhaM
PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit DhaM; Belongs to the PEP-utilizing enzyme family.
 
   
 0.466
dat_2
Diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.448
AML35995.1
4-aminobutyrate aminotransferase PuuE.
  
  
 0.448
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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