Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aceE_1Pyruvate dehydrogenase E1 component. (887 aa)    
Predicted Functional Partners:
lpd
Dihydrolipoyl dehydrogenase.
 
 0.999
aceF
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.999
maeB_2
NADP-dependent malic enzyme.
  
 
 0.957
porA
Putative pyruvate-flavodoxin oxidoreductase.
     
 0.954
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 
 0.923
pykF
Pyruvate kinase I; Belongs to the pyruvate kinase family.
  
 
 0.923
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.921
ilvM
Acetolactate synthase isozyme 2 small subunit.
     
 0.920
maeA
NAD-dependent malic enzyme.
    
 0.915
lldD_1
L-lactate dehydrogenase cytochrome; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
     
 0.913
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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