| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AML38619.1 | budB | EAG7_04889 | EAG7_01917 | Acetolactate synthase. | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | 0.927 |
| AML38619.1 | dmlA_3 | EAG7_04889 | EAG7_02252 | Acetolactate synthase. | D-malate dehydrogenase decarboxylating. | 0.943 |
| AML38619.1 | ilvA | EAG7_04889 | EAG7_04043 | Acetolactate synthase. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.943 |
| AML38619.1 | ilvB | EAG7_04889 | EAG7_04133 | Acetolactate synthase. | Acetolactate synthase isozyme 1 large subunit. | 0.926 |
| AML38619.1 | ilvC_1 | EAG7_04889 | EAG7_04041 | Acetolactate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.979 |
| AML38619.1 | ilvG | EAG7_04889 | EAG7_04047 | Acetolactate synthase. | Acetolactate synthase isozyme 2 large subunit. | 0.928 |
| AML38619.1 | ilvH | EAG7_04889 | EAG7_03255 | Acetolactate synthase. | Acetolactate synthase isozyme 3 small subunit. | 0.995 |
| AML38619.1 | ilvI_1 | EAG7_04889 | EAG7_05148 | Acetolactate synthase. | Acetolactate synthase large subunit. | 0.921 |
| AML38619.1 | ilvI_2 | EAG7_04889 | EAG7_03256 | Acetolactate synthase. | Acetolactate synthase isozyme 3 large subunit. | 0.928 |
| AML38619.1 | leuB | EAG7_04889 | EAG7_03259 | Acetolactate synthase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.964 |
| budB | AML38619.1 | EAG7_01917 | EAG7_04889 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase. | 0.927 |
| budB | dmlA_3 | EAG7_01917 | EAG7_02252 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | D-malate dehydrogenase decarboxylating. | 0.933 |
| budB | ilvA | EAG7_01917 | EAG7_04043 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.930 |
| budB | ilvB | EAG7_01917 | EAG7_04133 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase isozyme 1 large subunit. | 0.925 |
| budB | ilvC_1 | EAG7_01917 | EAG7_04041 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.968 |
| budB | ilvG | EAG7_01917 | EAG7_04047 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase isozyme 2 large subunit. | 0.925 |
| budB | ilvH | EAG7_01917 | EAG7_03255 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase isozyme 3 small subunit. | 0.986 |
| budB | ilvI_1 | EAG7_01917 | EAG7_05148 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.923 |
| budB | ilvI_2 | EAG7_01917 | EAG7_03256 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | Acetolactate synthase isozyme 3 large subunit. | 0.925 |
| budB | leuB | EAG7_01917 | EAG7_03259 | Acetolactate synthase, catabolic; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.954 |
