| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | ltaE_2 | EAG7_04043 | EAG7_02492 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Low specificity L-threonine aldolase. | 0.923 |
| ilvA | metL_1 | EAG7_04043 | EAG7_03909 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional aspartokinase/homoserine dehydrogenase 2. | 0.567 |
| ilvA | tdcB_2 | EAG7_04043 | EAG7_01013 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-threonine dehydratase catabolic TdcB. | 0.919 |
| ilvA | tdh | EAG7_04043 | EAG7_04247 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.906 |
| ilvA | thrA | EAG7_04043 | EAG7_03362 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.628 |
| ilvA | thrC | EAG7_04043 | EAG7_03360 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine synthase. | 0.951 |
| ltaE_2 | ilvA | EAG7_02492 | EAG7_04043 | Low specificity L-threonine aldolase. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.923 |
| ltaE_2 | tdcB_2 | EAG7_02492 | EAG7_01013 | Low specificity L-threonine aldolase. | L-threonine dehydratase catabolic TdcB. | 0.934 |
| ltaE_2 | tdh | EAG7_02492 | EAG7_04247 | Low specificity L-threonine aldolase. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.907 |
| ltaE_2 | thrC | EAG7_02492 | EAG7_03360 | Low specificity L-threonine aldolase. | Threonine synthase. | 0.925 |
| lysC | metL_1 | EAG7_03830 | EAG7_03909 | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | Bifunctional aspartokinase/homoserine dehydrogenase 2. | 0.962 |
| lysC | serC | EAG7_03830 | EAG7_02458 | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.596 |
| lysC | thrA | EAG7_03830 | EAG7_03362 | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.966 |
| lysC | thrB | EAG7_03830 | EAG7_03361 | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.919 |
| lysC | thrC | EAG7_03830 | EAG7_03360 | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | Threonine synthase. | 0.888 |
| metL_1 | ilvA | EAG7_03909 | EAG7_04043 | Bifunctional aspartokinase/homoserine dehydrogenase 2. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.567 |
| metL_1 | lysC | EAG7_03909 | EAG7_03830 | Bifunctional aspartokinase/homoserine dehydrogenase 2. | Lysine-sensitive aspartokinase 3; Belongs to the aspartokinase family. | 0.962 |
| metL_1 | serC | EAG7_03909 | EAG7_02458 | Bifunctional aspartokinase/homoserine dehydrogenase 2. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.761 |
| metL_1 | tdcB_2 | EAG7_03909 | EAG7_01013 | Bifunctional aspartokinase/homoserine dehydrogenase 2. | L-threonine dehydratase catabolic TdcB. | 0.567 |
| metL_1 | thrA | EAG7_03909 | EAG7_03362 | Bifunctional aspartokinase/homoserine dehydrogenase 2. | Bifunctional aspartokinase/homoserine dehydrogenase 1; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.996 |
