Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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trpRTrp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (108 aa)    
Predicted Functional Partners:
lepB
Signal peptidase I; Belongs to the peptidase S26 family.
   
    0.825
trpC
Tryptophan biosynthesis protein TrpCF.
 
   
 0.789
trpD
Bifunctional protein TrpGD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
   
 0.739
AML36953.1
UPF0231 protein; Belongs to the UPF0231 family.
  
     0.735
lpoA
Penicillin-binding protein activator LpoA; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family.
  
     0.730
slt
Soluble lytic murein transglycosylase.
 
     0.729
pheA
P-protein.
      
 0.672
yhjJ
Protein YhjJ.
  
     0.663
wecF_1
4-alpha-L-fucosyltransferase.
  
     0.660
AML38580.1
Hypothetical protein.
  
     0.647
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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