STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AML37751.1Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
cysG_1
Siroheme synthase 2; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 
 0.954
cysG_2
Siroheme synthase 1.
  
 
 0.954
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.944
hemX
Putative uroporphyrinogen-III C-methyltransferase.
  
 0.928
hemY
Protein HemY.
 
   
 0.883
AML34491.1
Delta-aminolevulinic acid dehydratase.
  
 
 0.718
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.718
holA
DNA polymerase III subunit delta.
 
     0.688
zapA
Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
 
     0.610
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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