STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvYHTH-type transcriptional regulator IlvY; Belongs to the LysR transcriptional regulatory family. (296 aa)    
Predicted Functional Partners:
ilvC_1
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.777
hcaR_1
Transcriptional activator protein LysR; Belongs to the LysR transcriptional regulatory family.
  
     0.746
dmlR_24
Putative HTH-type transcriptional regulator YafC; Belongs to the LysR transcriptional regulatory family.
  
     0.659
abgR_3
HTH-type transcriptional regulator TdcA; Belongs to the LysR transcriptional regulatory family.
  
     0.584
dmlR_25
Putative HTH-type transcriptional regulator LtrA; Belongs to the LysR transcriptional regulatory family.
  
     0.546
allS_5
Putative HTH-type transcriptional regulator YdhB; Belongs to the LysR transcriptional regulatory family.
  
     0.495
gcvA_5
Glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.
  
     0.475
cbiO_2
Putative molybdenum transport ATP-binding protein ModF.
  
     0.411
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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