| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ftsN | helD | EAG7_03916 | EAG7_02410 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Helicase IV. | 0.763 |
| ftsN | ompC | EAG7_03916 | EAG7_00360 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane protein C; Belongs to the Gram-negative porin family. | 0.763 |
| ftsN | ompF | EAG7_03916 | EAG7_02437 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane protein F. | 0.754 |
| ftsN | ompN_1 | EAG7_03916 | EAG7_00771 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane protein S1; Belongs to the Gram-negative porin family. | 0.754 |
| ftsN | ompN_2 | EAG7_03916 | EAG7_01253 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane protein S2. | 0.753 |
| ftsN | phoE | EAG7_03916 | EAG7_03060 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Outer membrane pore protein E; Belongs to the Gram-negative porin family. | 0.765 |
| ftsN | uspA | EAG7_03916 | EAG7_04349 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Universal stress protein A; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. | 0.739 |
| ftsN | uspA_2 | EAG7_03916 | EAG7_00856 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Universal stress protein C; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. | 0.705 |
| ftsN | yhcB_1 | EAG7_03916 | EAG7_04592 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Inner membrane protein YhcB. | 0.746 |
| ftsN | zapB | EAG7_03916 | EAG7_04206 | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | Cell division protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.764 |
| helD | ftsN | EAG7_02410 | EAG7_03916 | Helicase IV. | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. | 0.763 |
| helD | ompC | EAG7_02410 | EAG7_00360 | Helicase IV. | Outer membrane protein C; Belongs to the Gram-negative porin family. | 0.763 |
| helD | ompF | EAG7_02410 | EAG7_02437 | Helicase IV. | Outer membrane protein F. | 0.757 |
| helD | ompN_1 | EAG7_02410 | EAG7_00771 | Helicase IV. | Outer membrane protein S1; Belongs to the Gram-negative porin family. | 0.757 |
| helD | ompN_2 | EAG7_02410 | EAG7_01253 | Helicase IV. | Outer membrane protein S2. | 0.758 |
| helD | phoE | EAG7_02410 | EAG7_03060 | Helicase IV. | Outer membrane pore protein E; Belongs to the Gram-negative porin family. | 0.760 |
| helD | uspA | EAG7_02410 | EAG7_04349 | Helicase IV. | Universal stress protein A; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. | 0.750 |
| helD | uspA_2 | EAG7_02410 | EAG7_00856 | Helicase IV. | Universal stress protein C; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. | 0.599 |
| helD | yhcB_1 | EAG7_02410 | EAG7_04592 | Helicase IV. | Inner membrane protein YhcB. | 0.746 |
| helD | zapB | EAG7_02410 | EAG7_04206 | Helicase IV. | Cell division protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.730 |