STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsrGAutoinducer 2-degrading protein LsrG; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. (98 aa)    
Predicted Functional Partners:
lsrF_1
Putative aldolase LsrF.
 
 
 0.990
lsrB_1
Autoinducer 2-binding protein LsrB.
 
  
 0.988
lsrD_1
Autoinducer 2 import system permease protein LsrD; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.951
lsrK_2
Autoinducer 2 kinase LsrK.
 
 
 0.915
lsrC_1
Autoinducer 2 import system permease protein LsrC; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.822
lsrR_1
Transcriptional regulator LsrR.
 
  
 0.791
lsrA_1
Autoinducer 2 import ATP-binding protein LsrA.
  
  
 0.781
luxS
S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
  
 0.674
qseC
Sensor protein QseC.
      
 0.580
eutG_1
Alcohol dehydrogenase 4.
 
     0.572
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.