| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AML34140.1 | parE_2 | EAG7_00390 | EAG7_04782 | F protein. | DNA topoisomerase 4 subunit B. | 0.671 |
| AML37892.1 | parE_2 | EAG7_04157 | EAG7_04782 | Hypothetical protein. | DNA topoisomerase 4 subunit B. | 0.673 |
| AML38509.1 | AML38511.1 | EAG7_04779 | EAG7_04781 | Hypothetical protein. | Esterase YqiA. | 0.772 |
| AML38509.1 | cpdA_1 | EAG7_04779 | EAG7_04780 | Hypothetical protein. | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.966 |
| AML38509.1 | parE_2 | EAG7_04779 | EAG7_04782 | Hypothetical protein. | DNA topoisomerase 4 subunit B. | 0.631 |
| AML38511.1 | AML38509.1 | EAG7_04781 | EAG7_04779 | Esterase YqiA. | Hypothetical protein. | 0.772 |
| AML38511.1 | cpdA_1 | EAG7_04781 | EAG7_04780 | Esterase YqiA. | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.956 |
| AML38511.1 | parE_2 | EAG7_04781 | EAG7_04782 | Esterase YqiA. | DNA topoisomerase 4 subunit B. | 0.700 |
| cpdA_1 | AML38509.1 | EAG7_04780 | EAG7_04779 | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Hypothetical protein. | 0.966 |
| cpdA_1 | AML38511.1 | EAG7_04780 | EAG7_04781 | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Esterase YqiA. | 0.956 |
| cpdA_1 | parE_2 | EAG7_04780 | EAG7_04782 | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | DNA topoisomerase 4 subunit B. | 0.699 |
| dnaN_3 | gyrA | EAG7_04102 | EAG7_00354 | DNA polymerase III subunit beta. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.494 |
| dnaN_3 | metG | EAG7_04102 | EAG7_00503 | DNA polymerase III subunit beta. | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.411 |
| dnaN_3 | parE_2 | EAG7_04102 | EAG7_04782 | DNA polymerase III subunit beta. | DNA topoisomerase 4 subunit B. | 0.630 |
| dnaN_3 | polA | EAG7_04102 | EAG7_03964 | DNA polymerase III subunit beta. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.984 |
| gyrA | dnaN_3 | EAG7_00354 | EAG7_04102 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase III subunit beta. | 0.494 |
| gyrA | metG | EAG7_00354 | EAG7_00503 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.714 |
| gyrA | parC_1 | EAG7_00354 | EAG7_04788 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.631 |
| gyrA | parE_2 | EAG7_00354 | EAG7_04782 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase 4 subunit B. | 0.986 |
| gyrA | polA | EAG7_00354 | EAG7_03964 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.496 |