STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAPutative hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (114 aa)    
Predicted Functional Partners:
hypB
Hydrogenase isoenzymes nickel incorporation protein HypB.
 
 
 0.997
hypD
Hydrogenase isoenzymes formation protein HypD; Belongs to the HypD family.
  
 0.991
hypC
Hydrogenase isoenzymes formation protein HypC.
 
  
 0.989
hypE
Hydrogenase isoenzymes formation protein HypE.
  
 0.984
hypF
Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.942
hycE
Formate hydrogenlyase subunit 5.
 
 
 0.934
hycA
Formate hydrogenlyase regulatory protein HycA.
  
  
 0.723
nikR
Nickel-responsive regulator.
 
   
 0.721
hyfA
Formate hydrogenlyase subunit 2.
  
  
 0.702
slyD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD.
    
 
 0.695
Your Current Organism:
Klebsiella aerogenes
NCBI taxonomy Id: 548
Other names: ATCC 13048, Aerobacter aerogenes, CIP 60.86, DSM 30053, Enterobacter aerogenes, HAMBI 101, IFO 13534, K. aerogenes, KCTC 2190, Klebsiella mobilis, LMG 2094, LMG:2094, NBRC 13534, NCAIM B.01467, NCTC 10006
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