Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACP31874.1Putative S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa)    
Predicted Functional Partners:
metB
Cystathionine beta-lyases/cystathionine gamma- synthases.
 
 
 0.943
ACP33919.1
5'-methylthioadenosine nucleosidase / S- adenosylhomocysteine nucleosidase; Nucleoside phosphorylase.
 
 
 0.936
metE
Methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.909
yhcE
Putative epoxyalkane:coenzyme M transferase; Methionine synthase II (cobalamin-independent).
    
 0.909
mmuM
Homocysteine S-methyltransferase; Methionine synthase I (cobalamin-dependent), methyltransferase domain.
     
 0.906
metY
O-acetylhomoserine sulfhydrylase.
     
 0.902
metC
Cystathionine beta-lyase; Bifunctional PLP-dependent enzyme with beta- cystathionase and maltose regulon repressor activities.
     
 0.902
cysK
Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.862
hom
Homoserine dehydrogenase.
     
 0.809
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
     
  0.800
Your Current Organism:
Corynebacterium aurimucosum
NCBI taxonomy Id: 548476
Other names: C. aurimucosum ATCC 700975, Corynebacterium aurimucosum ATCC 700975, Corynebacterium aurimucosum CCUG 48176, Corynebacterium aurimucosum CIP 107436, Corynebacterium aurimucosum CN-1, Corynebacterium aurimucosum DSM 44827, Corynebacterium aurimucosum str. ATCC 700975, Corynebacterium aurimucosum strain ATCC 700975, Corynebacterium nigricans CN-1
Server load: low (26%) [HD]