| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aroT | hisA | cauri_0130 | cauri_1619 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.811 |
| aroT | hisB | cauri_0130 | cauri_1623 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Imidazoleglycerol-phosphate dehydratase. | 0.997 |
| aroT | hisC | cauri_0130 | cauri_1624 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.915 |
| aroT | hisD | cauri_0130 | cauri_1625 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.967 |
| aroT | hisF | cauri_0130 | cauri_1617 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.832 |
| aroT | hisH | cauri_0130 | cauri_1620 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.843 |
| aroT | hisN | cauri_0130 | cauri_0729 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase family. | 0.904 |
| aroT | pat | cauri_0130 | cauri_0650 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.907 |
| aroT | pheA | cauri_0130 | cauri_2397 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Prephenate dehydratase. | 0.913 |
| aroT | tyrA | cauri_0130 | cauri_0153 | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Prephenate dehydrogenase. | 0.957 |
| hisA | aroT | cauri_1619 | cauri_0130 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.811 |
| hisA | hisB | cauri_1619 | cauri_1623 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.998 |
| hisA | hisC | cauri_1619 | cauri_1624 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.981 |
| hisA | hisD | cauri_1619 | cauri_1625 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
| hisA | hisF | cauri_1619 | cauri_1617 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisA | hisH | cauri_1619 | cauri_1620 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisN | cauri_1619 | cauri_0729 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Archaeal fructose-16-bisphosphatase and related enzymes of inositol monophosphatase family. | 0.515 |
| hisA | pat | cauri_1619 | cauri_0650 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.818 |
| hisB | aroT | cauri_1623 | cauri_0130 | Imidazoleglycerol-phosphate dehydratase. | Aromatic amino acid aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.997 |
| hisB | hisA | cauri_1623 | cauri_1619 | Imidazoleglycerol-phosphate dehydratase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.998 |