Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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uvrCExcinuclease ABC, subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (684 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC, subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.995
uvrA1
Excinuclease ABC, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.896
ACP32788.1
Putative membrane protein.
       0.834
uvrA2
Excinuclease ATPase subunit.
 
 
 0.800
ACP32073.1
ABC-type sugar transport systems, ATPase components.
 
 
 0.792
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.772
ribA
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.767
pcrA
Putative ATP-dependent DNA helicase II; Superfamily I DNA and RNA helicases.
 
  
 0.759
ACP32295.1
Putative ATP-dependent DNA helicase II; Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
  
  
 0.744
ACP32296.1
Putative ATP-dependent DNA helicase II; Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.
  
  
 0.744
Your Current Organism:
Corynebacterium aurimucosum
NCBI taxonomy Id: 548476
Other names: C. aurimucosum ATCC 700975, Corynebacterium aurimucosum ATCC 700975, Corynebacterium aurimucosum CCUG 48176, Corynebacterium aurimucosum CIP 107436, Corynebacterium aurimucosum CN-1, Corynebacterium aurimucosum DSM 44827, Corynebacterium aurimucosum str. ATCC 700975, Corynebacterium aurimucosum strain ATCC 700975, Corynebacterium nigricans CN-1
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