| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACP33003.1 | cmk2 | cauri_1410 | cauri_1321 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Cytidylate kinase. | 0.900 |
| ACP33003.1 | dgt | cauri_1410 | cauri_1795 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. | 0.900 |
| ACP33003.1 | dut1 | cauri_1410 | cauri_1448 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
| ACP33003.1 | guaA | cauri_1410 | cauri_0485 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.908 |
| ACP33003.1 | guaB2 | cauri_1410 | cauri_0482 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Putative inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase/GMP reductase. | 0.926 |
| ACP33003.1 | nadD | cauri_1410 | cauri_1855 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.909 |
| ACP33003.1 | nagD | cauri_1410 | cauri_1753 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Pyridoxal phosphate phosphatase; Predicted sugar phosphatases of the HAD superfamily; Belongs to the HAD-like hydrolase superfamily. | 0.915 |
| ACP33003.1 | purH | cauri_1410 | cauri_0810 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.906 |
| ACP33003.1 | thyA | cauri_1410 | cauri_0792 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.905 |
| ACP33003.1 | tmk | cauri_1410 | cauri_0673 | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Thymidylate kinase. | 0.916 |
| cmk2 | ACP33003.1 | cauri_1321 | cauri_1410 | Cytidylate kinase. | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.900 |
| cmk2 | guaA | cauri_1321 | cauri_0485 | Cytidylate kinase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.572 |
| cmk2 | guaB2 | cauri_1321 | cauri_0482 | Cytidylate kinase. | Putative inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase/GMP reductase. | 0.480 |
| cmk2 | nagD | cauri_1321 | cauri_1753 | Cytidylate kinase. | Pyridoxal phosphate phosphatase; Predicted sugar phosphatases of the HAD superfamily; Belongs to the HAD-like hydrolase superfamily. | 0.925 |
| dgt | ACP33003.1 | cauri_1795 | cauri_1410 | dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.900 |
| dgt | nagD | cauri_1795 | cauri_1753 | dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. | Pyridoxal phosphate phosphatase; Predicted sugar phosphatases of the HAD superfamily; Belongs to the HAD-like hydrolase superfamily. | 0.909 |
| dut1 | ACP33003.1 | cauri_1448 | cauri_1410 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative 5'-nucleotidase family protein; 5-nucleotidase/23-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.900 |
| dut1 | nagD | cauri_1448 | cauri_1753 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Pyridoxal phosphate phosphatase; Predicted sugar phosphatases of the HAD superfamily; Belongs to the HAD-like hydrolase superfamily. | 0.902 |
| dut1 | thyA | cauri_1448 | cauri_0792 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.940 |
| dut1 | tmk | cauri_1448 | cauri_0673 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase. | 0.937 |