STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (373 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 0.999
hemB
Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family.
 
 0.999
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.997
ADI67048.1
Putative uroporphyrinogen decarboxylase; COG: COG0407; Pfam: PF01208; InterPro: IPR000257; Belongs to the uroporphyrinogen decarboxylase family.
 
 0.980
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639.
  
 0.974
ADI67049.1
Hypothetical protein; Pfam: PF01593.
  
 0.971
ADI66621.1
Aminotransferase, class III; COG: COG0001; Pfam: PF00202; InterPro: IPR005814; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.884
ADI66555.1
Aminotransferase, class III; COG: COG0001; Pfam: PF00202; InterPro: IPR005814; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.868
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.861
hemE
Uroporphyrinogen decarboxylase; COG: COG0407; Pfam: PF01208; InterPro: IPR000257; Belongs to the uroporphyrinogen decarboxylase family.
 
 
 0.800
Your Current Organism:
Mobiluncus curtisii
NCBI taxonomy Id: 548479
Other names: Falcivibrio vaginalis ATCC 43063, M. curtisii ATCC 43063, Mobiluncus curtisii ATCC 43063, Mobiluncus curtisii str. ATCC 43063, Mobiluncus curtisii strain ATCC 43063
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