STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuB
Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 0.999
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.994
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.986
ADI67806.1
2-isopropylmalate synthase/homocitrate synthase family protein; COG: COG0119; Pfam: PF00682,PF08502; InterPro: IPR005675; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.981
ilvN
Acetolactate synthase, small subunit; COG: COG0440; Pfam: PF01842; InterPro: IPR004789.
  
  
 0.874
ilvD
Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family.
  
  
 0.863
thrC
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.821
ADI66618.1
Glycine radical domain protein; COG: COG1882; Pfam: PF01228.
     
 0.819
ADI66619.1
Putative formate C-acetyltransferase; COG: COG1882; Pfam: PF02901,PF01228; InterPro: IPR004184.
     
 0.819
Your Current Organism:
Mobiluncus curtisii
NCBI taxonomy Id: 548479
Other names: Falcivibrio vaginalis ATCC 43063, M. curtisii ATCC 43063, Mobiluncus curtisii ATCC 43063, Mobiluncus curtisii str. ATCC 43063, Mobiluncus curtisii strain ATCC 43063
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