STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpPEndopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. (294 aa)    
Predicted Functional Partners:
clpP-3
Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.993
ADI67558.1
Phage portal protein, HK97 family; COG: COG4695; Pfam: PF04860; InterPro: IPR006427.
    0.987
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
  
 
 0.947
ADI67556.1
Phage major capsid protein, HK97 family; COG: COG4653; Pfam: PF05065; InterPro: IPR006444.
 
    0.920
ADI66747.1
ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family.
  
 
 0.878
ADI66858.1
Putative ATP-dependent chaperone protein ClpB; COG: COG0542; Pfam: PF02861,PF00004,PF07724; InterPro: IPR003959; Belongs to the ClpA/ClpB family.
  
 
 0.878
ADI67560.1
Putative phage terminase, large subunit; COG: COG4626; Pfam: PF03354; InterPro: IPR005021.
 
     0.748
ADI67711.1
Phage portal protein, HK97 family; Pfam: PF04860; InterPro: IPR006944.
    0.738
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.723
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
   
 
 0.720
Your Current Organism:
Mobiluncus curtisii
NCBI taxonomy Id: 548479
Other names: Falcivibrio vaginalis ATCC 43063, M. curtisii ATCC 43063, Mobiluncus curtisii ATCC 43063, Mobiluncus curtisii str. ATCC 43063, Mobiluncus curtisii strain ATCC 43063
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.