node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADI66982.1 | ADI67788.1 | HMPREF0573_10663 | HMPREF0573_11469 | Peptidase, S54 family; Pfam: PF01694; InterPro: IPR002610. | Hypothetical protein. | 0.788 |
ADI66982.1 | tatA | HMPREF0573_10663 | HMPREF0573_11468 | Peptidase, S54 family; Pfam: PF01694; InterPro: IPR002610. | Twin arginine-targeting protein translocase, TatA/E family; Pfam: PF02416. | 0.831 |
ADI67788.1 | ADI66982.1 | HMPREF0573_11469 | HMPREF0573_10663 | Hypothetical protein. | Peptidase, S54 family; Pfam: PF01694; InterPro: IPR002610. | 0.788 |
ADI67788.1 | guaA | HMPREF0573_11469 | HMPREF0573_10214 | Hypothetical protein. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.986 |
ADI67788.1 | moaC | HMPREF0573_11469 | HMPREF0573_11470 | Hypothetical protein. | Molybdenum cofactor biosynthesis protein C; COG: COG0315; Pfam: PF01967; InterPro: IPR002820. | 0.612 |
ADI67788.1 | tatA | HMPREF0573_11469 | HMPREF0573_11468 | Hypothetical protein. | Twin arginine-targeting protein translocase, TatA/E family; Pfam: PF02416. | 0.745 |
ADI67788.1 | tatC | HMPREF0573_11469 | HMPREF0573_11467 | Hypothetical protein. | Putative twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.980 |
ADI68217.1 | tatA | HMPREF0573_11898 | HMPREF0573_11468 | Hypothetical protein. | Twin arginine-targeting protein translocase, TatA/E family; Pfam: PF02416. | 0.611 |
ftsY | secA | HMPREF0573_10180 | HMPREF0573_10405 | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.979 |
ftsY | secD | HMPREF0573_10180 | HMPREF0573_11743 | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.806 |
ftsY | secY | HMPREF0573_10180 | HMPREF0573_10318 | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.995 |
ftsY | tatA | HMPREF0573_10180 | HMPREF0573_11468 | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Twin arginine-targeting protein translocase, TatA/E family; Pfam: PF02416. | 0.679 |
ftsY | tatC | HMPREF0573_10180 | HMPREF0573_11467 | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Putative twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.774 |
guaA | ADI67788.1 | HMPREF0573_10214 | HMPREF0573_11469 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Hypothetical protein. | 0.986 |
guaA | moaC | HMPREF0573_10214 | HMPREF0573_11470 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Molybdenum cofactor biosynthesis protein C; COG: COG0315; Pfam: PF01967; InterPro: IPR002820. | 0.406 |
guaA | secY | HMPREF0573_10214 | HMPREF0573_10318 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.452 |
guaA | tatA | HMPREF0573_10214 | HMPREF0573_11468 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Twin arginine-targeting protein translocase, TatA/E family; Pfam: PF02416. | 0.998 |
guaA | tatC | HMPREF0573_10214 | HMPREF0573_11467 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Putative twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.446 |
moaC | ADI67788.1 | HMPREF0573_11470 | HMPREF0573_11469 | Molybdenum cofactor biosynthesis protein C; COG: COG0315; Pfam: PF01967; InterPro: IPR002820. | Hypothetical protein. | 0.612 |
moaC | guaA | HMPREF0573_11470 | HMPREF0573_10214 | Molybdenum cofactor biosynthesis protein C; COG: COG0315; Pfam: PF01967; InterPro: IPR002820. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.406 |