STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (437 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
    0.902
ADI67851.1
Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
 
   
 0.854
ADI66823.1
glutamyl-Q tRNA(Asp) synthetase; COG: COG0008; Pfam: PF00749; InterPro: IPR000924; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
     0.799
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.729
ADI68022.1
Putative ribosomal RNA small subunit methyltransferase B; COG: COG0144; Pfam: PF01029,PF01189; InterPro: IPR001678; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.625
ADI67853.1
IMP dehydrogenase family protein; COG: COG0516; Pfam: PF00478; InterPro: IPR001093.
  
    0.577
ADI67854.1
ABC transporter, ATP-binding protein; COG: COG1132; Pfam: PF00664,PF00005; InterPro: IPR003593.
       0.553
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.551
aspS
aspartate--tRNA ligase; COG: COG0173; Pfam: PF00152,PF02938; InterPro: IPR004524.
 
    0.547
ADI68063.1
Putative preprotein translocase, YajC subunit.
  
    0.523
Your Current Organism:
Mobiluncus curtisii
NCBI taxonomy Id: 548479
Other names: Falcivibrio vaginalis ATCC 43063, M. curtisii ATCC 43063, Mobiluncus curtisii ATCC 43063, Mobiluncus curtisii str. ATCC 43063, Mobiluncus curtisii strain ATCC 43063
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