STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceA_1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)    
Predicted Functional Partners:
aceB
Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family.
 
 0.999
aceK
Bifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.941
ghrA_1
Glyoxylate/hydroxypyruvate reductase A; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.934
ghrA
Bifunctional glyoxylate/hydroxypyruvate reductase A; Catalyzes the formation of glycolate and glycerate from glyoxylate and hydroxypyruvate, respectively; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.934
acnA_3
Aconitate hydratase 1; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.932
acnB_3
Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.913
ghrB_1
Bifunctional glyoxylate/hydroxypyruvate reductase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.905
eda
Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.905
pta_1
Phosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.817
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
  
 0.758
Your Current Organism:
Pantoea agglomerans
NCBI taxonomy Id: 549
Other names: ATCC 27155, Bacillus milletiae, Bacterium herbicola, CCUG 539, CFBP 3845, CIP 57.51, DSM 3493, Enterobacter agglomerans, Erwinia herbicola, Erwinia milletiae, ICMP 12534, ICPB 3435, NBRC 102470, NCTC 9381, P. agglomerans, Pantoea herbicola, Pantoea sp. SL1_M5, Pseudomonas herbicola, bacterium G33-1
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